Molecularly imprinted polymer (MIP) technologies hold great promise not only as sensors for detecting specific molecules but also for the controlled release of drugs and active compounds in precise concentrations. This dual functionality is important in advancing targeted and efficient drug delivery systems. Research into MIPs and their adsorption/desorption mechanisms is therefore critical. In this context, geraniol - a component of essential oils (EOs) - is incorporated into studies to evaluate adsorption kinetics and explore its therapeutic potential. Geraniol is rich of biological effects such as anti-inflammatory, antioxidant or antitumor. However, there is lack of information about this molecule effectiveness, delivery and safety. Essential oils (EOs) are naturally derived mixtures with some therapeutic applications. However, traditional delivery of therapeutics systems still struggles with issues such as instability, low bioavailability, uncontrolled release of active compounds, and rapid degradation. Integrating EOs into MIP-based delivery systems addresses these challenges by enhancing stability, enabling controlled release, and providing targeted delivery. Molecular imprinting techniques, including covalent, non-covalent, and semi-covalent imprinting, allow for the creation of highly selective binding cavities, significantly improving the efficacy and therapeutic benefits of EOs.[1] Innovative treatment strategies are especially critical for rare diseases such as Duchenne muscular dystrophy (DMD), where personalised and adjusted treatment is important with specifics of therapeutics used. Current therapies, like corticosteroids, are often accompanied by severe side effects, underscoring the need for safer, more effective alternatives. Nutraceuticals, including herbal extracts and EOs, present a promising avenue for novel drug delivery systems. Combining EOs with MIP technology offers the potential for improved drug formulations, enhancing precision, safety, and therapeutic efficacy.[2] By leveraging controlled release and targeted action, EO-based active component delivery systems may provide better muscle function and mental health outcomes in DMD patients. While preliminary research indicates promise, further studies are essential to validate the potential of EO-based MIP systems in addressing therapeutic needs for DMD and other conditions.
TRANSILATIONAL APPROACH OF MOLECULAR IMPRINTED POLYMERS INTEGRATION WITH ESSENTIAL OILS
Greta Kasputė1, 2, Urtė Prentice1, 2, 3
1 State Research Institute Centre for Innovative Medicine, Santariskiu St. 5, LT-08410, Vilnius, Lithuania.
2 Department of Nanotechnology, State Research Institute Center for Physical Sciences and Technology (FTMC), Sauletekio Av. 3, LT-10257 Vilnius, Lithuania.
3 Department of Physical Chemistry, Institute of Chemistry, Faculty of Chemistry and Geosciences, Vilnius University, Naugarduko St. 24, LT-03225 Vilnius, Lithuania.
[1] G. Kaspute, A. Ramanavicius, U. Prentice, Molecular Imprinting Technology for Advanced Delivery of Essential Oils. Polymers 2024, 16, 2441. https://doi.org/10.3390/polym16172441
[2] G. Kaspute, B.D. Arunagiri, R. Alexander, A. Ramanavicius, U. Samukaite-Bubniene, Development of Essential Oil Delivery Systems by ‘Click Chemistry’ Methods: Possible Ways to Manage Duchenne Muscular Dystrophy. Materials 2023, 16, 6537. https://doi.org/10.3390/ma16196537