ᐊ P2-34
Open Readings 2023 • P2-35
P2-36 ᐅ

METAL OXIDE NANOSTRUCTURES IN CHEMICAL SENSORS AND BIOSENSORS

Vincentas Mačiulis1, Almira Ramanavičienė2, Miglė Stančiauskaitė2, Ieva Plikusienė2

1 Department of Nanotechnology, Center for Physical Sciences and Technology, Lithuania

2 NanoTechnas - Nanotechnology and Materials Science Center, Institute of Chemistry, Vilnius University, Lithuania

[email protected]

Metal oxide nanostructures have proven effective in the development of chemical and biosensors due to their unique optical, electrical, and physical properties. Recent advancements in synthesis technologies have allowed for more control over nanostructure production, resulting in increased sensor performance and reliability. Applications include detection of environmental pollutants and biological materials. The use of metal oxide nanostructures in chemical sensors and biosensors is a rapidly growing field with great potential for practical impact in a variety of industries and research areas [1].

Metal oxide nanostructures can be fabricated by a simple chemical precipitation reaction. However, using wet chemical processes alone can make it challenging to acquire accurate dimensions and innovative form of nanostructures. As a result, the use of templates, external energy (thermal or electrical), and pressure can result in more control and variety in the morphology of metal oxide nanostructures produced. A variety of methods for fabricating metal oxide nanostructures are being investigated: synthesis in reverse microemulsions, dendrimer templating, chemical bath deposition, electrodeposition, chemical vapor deposition, and atomic layer deposition [2], [3].

Biosensing and chemical sensing have gained interest in the last decade and are used in many fields: food, environment and healthcare. Both applications rely on an interaction of the analyte with a surface-bound material or chemical interface. Biosensors are typically classified according to the type of bioreceptor (enzyme, antibody, DNA, cells, biomimetic) and signal transmission (optical, calorimetric, piezoelectric, electrochemical). Chemical sensors, on the other hand, are classified by their transmission method (optical, electrical, and mechanical) and by the structure/composition of the chemical interface (metal, metal oxide, and metal-semiconductor). Therefore, in both sensor applications, metal oxide nanostructures can be used to modify/amplify the signal transduction [4], [5].

[1] V. Maciulis, A. Ramanaviciene, and I. Plikusiene, "Recent Advances in Synthesis and Application of Metal Oxide Nanostructures in Chemical Sensors and Biosensors," Nanomaterials, vol. 12, no. 24, 2022, doi: 10.3390/nano12244413.

[2] V. Maciulis et al., "Porous aluminium oxide coating for the development of spectroscopic ellipsometry based biosensor: Evaluation of human serum albumin adsorption," Coatings, vol. 10, no. 11, 2020, doi: 10.3390/coatings10111018.

[3] I. Plikusiene et al., "Total internal reflection ellipsometry for kinetics-based assessment of bovine serum albumin immobilization on ZnO nanowires," J. Mater. Chem. C, vol. 9, no. 4, pp. 1345–1352, 2021, doi: 10.1039/d0tc05193d.

[4] A. Ramanaviciene et al., "Magneto-Immunoassay for the Detection and Quantification of Human Growth Hormone," Biosensors, vol. 12, no. 2, 2022, doi: 10.3390/bios12020065.

[5] L. Sakalauskiene, A. Popov, A. Kausaite-Minkstimiene, A. Ramanavicius, and A. Ramanaviciene, "The Impact of Glucose Oxidase Immobilization on Dendritic Gold Nanostructures on the Performance of Glucose Biosensors," Biosensors, vol. 12, no. 5, p. 320, 2022, doi: 10.3390/bios12050320.