Nimesulide (N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide, empirical formula C13H12N2O5S) is a non-steroidal anti-inflammatory drugs (NSAIDs) to be treated for pain and inflammation. It can also perform antipyretic activities [1].
The aim of the study was to prepare and characterize the hydrogel carbopol containing active component - nimesulide loaded on the nanohydroxyapatite matrix for skin application.
The obtained gel with the nimesulide incorporated on the nanohydroxyapatite was tested in terms of pH, viscosity, homogeneity and the polymer-active substance interactions that take place in the preparation were considered.
The spectroscopic, rheological, thermogravimetric analysis and swelling studies were performed to evaluate the effect of on drug release and stability of the hydrogel. Greater swelling was observed at a pH slightly higher than the physiological pH of the skin. The results revealed that 50% wt. drug was released from the hydrogel in 6 h at pH 5.6 and 32°C (Fig. 1).
The rheograms for the formulation was measured at 25 and 32°C and corresponding as a storage temperature and a skin temperature, respectively.
The rheological properties and extended the nimesulide release of hydrogel make a potential candidate for controlled delivery of the drug.